1.1 Overview

1.2 Tips For Navigating This Section

1.3 The Importance of Research

2.1. Basic Cancer Biology

2.11 The Cell
2.12 The Cell Cycle
2.13 Cancer Genetics
2.14 Genetic Structure
2.15 The Language of Biology
2.16 What Causes Cancer?
2.17 Genetic Variation

2.2. Advances in Cancer Research

2.21 A Cancer Research Timeline
2.22 The “Six Hallmarks” of Cancer: Circa 2000
2.23 Oncogenes, Tumor - Suppressor Genes and DNA Repair Genes
2.24 Research Hallmarks: Circa Today

• Infectious Agents
• Tumor Genetics
• Tumor Epigenetics
• Angiogenesis
• The Tumor Microenvironment
• The Immune System
• Drug Metabolism

2.25 Summary: A Daunting Challenge

2.3. The ‘Omics’ Revolution & Beyond

2.31 Genomics
2.32 Proteomics
2.33 Metabolomics
2.34 Systems Biology
2.35 Bioinformatics
2.36 Personalized Medicine

 

3.1. Background

3.11 The Four Fields of Research
3.12 The Scientific Method
3.13 Research Technology

3.2. Basic Research

3.21 Basic Research Scientists
3.22 Scientific Disciplines
3.23 Tools of The Trade

3.3. Translational Research

3.31 Translational Research Scientists
3.32 Translational Research
3.33 Pre-Clinical Research
3.34 Correlative Science
3.35 Biospecimen Issues

3.4. Clinical Research

3.41 Clinical Research Personnel
3.42 Clinical Trial Background Issues
3.43 Clinical Trial Phases for Cytotoxic Therapies
3.44 Clinical Trial Phases for Targeted Therapy
3.45 Other Types of Clinical Trials
3.46 Ethical Issues
3.47 Who conducts Clinical Trials?

3.5. Epidemiological Research

3.51 Epidemiology Research Scientists
3.52 Types of Epidemiology Studies
3.53 Meta Analysis
3.54 Future Directions
3.55 Glossary of Epidemiology Terms

 

4.1 Review of Bench to Bedside Research

4.11 Basic Research
4.12 Translational or Preclinical Research
4.13 Clinical Research

4.2 Stages of Drug Development Discovery

4.21 Target Identification
4.22 Lead Identification
4.23 Lead Optimization
4.24 Candidate Drug Nomination
4.25 New biological Information

4.3 The Regulatory Process

4.31 Application Needed Before A Clinical Trial
4.32 Application Needed After A Clinical Trial
4.33 Types of FDA review
4.44 Other Issues

4.4 Economics of Drug Development

4.5 Stakeholders

4.51 Industry
4.52 Food & Drug Administration
4.53 National Cancer Institute (NCI)
4.54 Researchers
4.55 Sources of Funding
4.56 Doctors
4.57 Patient Advocate Groups
4.58 Patients

4.6 Featured Stakeholders: Patient Advocacy Groups

4.7 CISN Summary of Drug Development Challenges

5.1 Targeted Therapy

5.11 Why Targeted Therapies Are Important
5.12 How Do Targeted Therapies Work
5.13 The Promise of Targeted Therapy

5.2 Angiogenesis Inhibitors

5.21 Why Angiogenesis Inhibitors Are Important
5.22 How Do Angiogenesis Inhibitors Work?
5.23 The Promise of Angiogenesis Inhibitors

5.3 Immunotherapy / Cancer Vaccines

5.31 Why Immunotherapy Is Important
5.32 How Does Immunotherapy Work?
5.33 The Promise of Immunotherapy

5.4 Gene Therapy

5.41 Why Gene Therapy Is Important
5.42 How Does Gene Therapy Work?
5.43 The Promise of Gene Therapy

5.5 Nanotechnology

5.51 Why Nanotechnology Is Important
5.52 How Does Nanotechnology Work?
5.53 The Promise of Nanotechnology

5.6 Tumor Markers

5.61 Why Tumor Markers Are Important
5.62 How Do Tumor Markers Work?
5.63 The Promise of Tumor Markers

5.7 Molecular Diagnostics

5.71 Why Molecular Diagnostics Are Important
5.72 How Does Molecular Diagnostics Work
5.73 The Promise of Molecular Diagnostics